Science

lightbulb
One of the unspoken benefits of beer is that it’s a very useful relaxation tool. After a hard, stressful day of work, a tasty beer is just the thing to calm one’s nerves. It would be nearly impossible to quantify, but I have to wonder how much better off many people are because of the relaxation afforded them through the simple act of drinking a beer. How many didn’t do something that they might later regret had they remained tense, stressed and on edge. It’s worth considering, especially as the neo-prohibitionists increasingly insist that beer has no health benefits. But the mental health benefits that most of us get from a calming glass of beer can’t be ignored.

But there’s apparently one more mental health benefit to a beer, as reported recently in the Wall Street Journal (and thanks to Jeff B. for sending me the link). The essay, by Jonah Lehrer, is How To Be Creative, and the teaser subtitle give a nutshell account of what’s to come. “The image of the ‘creative type’ is a myth. Jonah Lehrer on why anyone can innovate—and why a hot shower, a cold beer or a trip to your colleague’s desk might be the key to your next big idea.” The fascinating story is about where creativity and innovation come from, something science has only very recently even tried to explain. The essay discusses several theories and gives examples of different ways that creativity is sparked and influenced. One of those, of course, is through drinking a glass of beer.

Interestingly, Mr. Beeman and his colleagues have found that certain factors make people much more likely to have an insight, better able to detect the answers generated by the aSTG [superior anterior temporal gyrus]. For instance, exposing subjects to a short, humorous video—the scientists use a clip of Robin Williams doing stand-up—boosts the average success rate by about 20%.

Alcohol also works. Earlier this year, researchers at the University of Illinois at Chicago compared performance on insight puzzles between sober and intoxicated students. The scientists gave the subjects a battery of word problems known as remote associates, in which people have to find one additional word that goes with a triad of words. Here’s a sample problem:

Pine Crab Sauce

In this case, the answer is “apple.” (The compound words are pineapple, crab apple and apple sauce.) Drunk students solved nearly 30% more of these word problems than their sober peers.

What explains the creative benefits of relaxation and booze? The answer involves the surprising advantage of not paying attention. Although we live in an age that worships focus — we are always forcing ourselves to concentrate, chugging caffeine — this approach can inhibit the imagination. We might be focused, but we’re probably focused on the wrong answer.

And this is why relaxation helps: It isn’t until we’re soothed in the shower or distracted by the stand-up comic that we’re able to turn the spotlight of attention inward, eavesdropping on all those random associations unfolding in the far reaches of the brain’s right hemisphere. When we need an insight, those associations are often the source of the answer.

So if you’re having trouble with your latest creative project, stuck somewhere with no solution in sight? Relax, don’t worry, have a beer. That may prove to be just the thing to free your mind and in the process unlock the creativity necessary to solve your problem. Liquid gold indeed.

{ 3 comments }

ethanol
This is one of the coolest, albeit nerdy, songs I’ve heard since Tom Lehrer was doing the Vatican Rag and singing about the Elements. And thanks to Peter H. for sending me the link. It’s a St. Patrick’s Day song by a biologist, known only as Cadamole, who apparently lives in Washington, D.C. He sings about the biology of beer and … well, just listen to it for yourself. Enjoy!

And below are the lyrics so you can sing along:

In the year of our lord eighteen hundred and eleven
On March the seventeenth day
I will raise up a beer and I’ll raise up a cheer
For Saccharomyces cerevisiae
Here’s to brewers yeast, that humblest of all beasts
Producing carbon gas reducing acetaldehyde
But my friends that isn’t all — it makes ethyl alcohol
That is what the yeast excretes and that’s what we imbibe

Anaerobic isolation
Alcoholic fermentation
NADH oxidation
Give me a beer

[CHORUS]

My intestinal wall absorbs that ethanol
And soon it passes through my blood-brain barrier
There’s a girl in the next seat who I didn’t think that sweet
But after a few drinks I want to marry her
I guess it’s not surprising, my dopamine is rising
And my glutamate receptors are all shot
I’d surely be bemoaning all the extra serotonin
But my judgment is impaired and my confidence is not

Allosteric modulation
No Long Term Potentiation
Hastens my inebriation
Give me a beer

[CHORUS]

When ethanol is in me, some shows up in my kidneys
And inhibits vasopressin by degrees
A decrease in aquaporins hinders water re-absorption
And pretty soon I really have to pee
Well my liver breaks it down so my body can rebound
By my store of glycogen is soon depleted
And tomorrow when I’m sober I will also be hungover
Cause I flushed electrolytes that my nerves and muscles needed

Diuretic activation
Urination urination
Urination dehydration
Give me a beer

[CHORUS]

{ 4 comments }

fruitfly
The March issue of Science, touted as “the world’s leading journal of original scientific research, global news and commentary, included an article entitled Sexual Deprivation Increases Ethanol Intake in Drosophila. Which may not mean much, until you realize that in plain English it’s essentially “fruit flies who’ve had their sexual advances rejected drink more alcohol.” Here’s the abstract:

The brain’s reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation reduced, neuropeptide F (NPF) levels. Activation or inhibition of the NPF system in turn reduced or enhanced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF–NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly.

Science Magazine’s News Blog featured the article in more layman’s terms as Sexually Rejected Flies Turn to Booze, and described the results as follows.

Offer a male fruit fly a choice between food soaked in alcohol and its nonalcoholic equivalent, and his decision will depend on whether he’s mated recently or been rejected by a female. Flies that have been given the cold shoulder are more likely to go for the booze, researchers have found. It’s the first discovery, in fruit flies, of a social interaction that influences future behavior.

Apparently that’s not the outcome the scientists expected.

The researchers expected all of the flies to prefer alcohol, but that’s not what they found. “You see that the mated males actually have an aversion to the alcohol-containing food,” Shohat-Ophir says. “And the rejected males have a high preference to that food with alcohol.” On average, the rejected males drank four times more alcohol than the mated ones, her team reports.

In the New York Times’ coverage — Learning From the Spurned and Tipsy Fruit Fly — they make the leap to human addiction, which I find a little troubling. “Fruit flies apparently self-medicate just like many humans do, drowning their sorrows or frustrations for some of the same reasons.” Which is okay, so far, but then they quote an alcohol addiction researcher who was not involved in the study, Dr. Markus Heilig, who believes the study “also supported new approaches to treating alcohol dependence,” including the investigation of “several compounds aimed at blunting alcohol urges.” And earlier in the Times’ reporting, they state that the study “suggests that some elements of the brain’s reward system have changed very little during evolution, and these include some of the mechanisms that support addiction.”

But that presupposes that the urge to drink alcohol is always bad, something that people should never do, and that it necessarily leads to addiction. And that, of course, it not the least bit true. Once upon a time, it meant the difference between living long enough to procreate and dying without issue. When it was safer to drink than the water, those humans with a greater tolerance for alcohol survived while those that couldn’t did not. If you’re reading this right now, it’s likely you can thank your ancient ancestors’ ability to handle their drink.

Even today, people who drink moderately tend to outlive those who never drink alcohol. Even those that drink heavily still tend to outlive those who never drink alcohol. It’s just that small fraction of the population that cannot handle alcohol and can be considered alcoholics, whether genetic or social or simply weak-willed. And for their failings, the world is cursed with neo-prohibitionists hell bent on the idea if even one person can’t handle alcohol, then dagnabbit no one should be able to enjoy it.

But so much of this type of research seems to play into their hands, making the assumption — very, very wrong in my opinion — that alcohol is bad for people, and bad for society, and that drinking alcohol always leads to alcoholism. It’s usually the starting premise. But it’s a false premise, because the majority of people who drink alcohol do so responsibly and in moderation and do not fall prey to alcoholism after their first (or tenth, or 100th or 1000th) sip.

And like the rejected fruit fly, sometimes a beer is just the thing to help get over a bitter rejection, or just a long, tough day at work. The calming effect of a beer after work or with dinner is part of a healthy lifestyle for many, many people. For a majority of people, there’s nothing wrong with that, and it does not signal the onset of addiction or any sort of problem whatsoever. And that’s my takeaway from the fruit fly, too. Sometimes you just need a beer to drown your sorrows.

drunk-fruitfly

{ 0 comments }

global-warming
This is fairly clever. A blog dedicated to chronicling the science surrounding climate change, Real Climate, posted a chart comparing the chronology of climate change from 1960 through the year 2100. It was originally created by Artist As Citizen, which is described as “a collaborative, student-driven blend of art and journalism. The infographic is called Risks and Impacts of Increasing Beer Temperature.

beer-climate-change
You can view the full size version of the image here.

I’m not sure about that tagline. “If we can pay as much attention to the Earth as we do to our beer, we probably wouldn’t need to worry about global warming.” I’m pretty sure we can do both fairly easily. And it’s not as if beer drinking is what’s distracting us from addressing global warming.

Still it’s interesting to see climate change described in terms of the serving temperature of beer. Below are the 8 stages of global warming split in two so they can bee seen a little larger, and consequently so the text is more readable, too.

1960—2020

beer-climate-change-left

2040—2100

beer-climate-change-right

{ 0 comments }

Hangover Cure News

by Jay Brooks on December 6, 2011 · 2 comments

in Just For Fun,News,Related Pleasures

hangover
If you’ve ever looked at the science behind hangovers or endured enough of them, you probably already know that time is really the only cure for one. But when you’re feeling that bad, hope tends to spring eternal; and so hangover cures represent a pretty healthy business, bringing in untold millions of dollars. A hungover fool and his money are soon parted.

We all have our own preferred remedy. Mine is entirely preventative. Before going to bed, I take three Advils and a B-vitamin. More often than not, I wake up feeling fine. I also drink a lot of water, both during a drinking session and before retiring. I don’t think of it as a cure — indeed, I don’t believe there can actually be a cure — but for me it tends to head off the symtoms before they manifest themselves as discomfort or downright pain.

But companies keep taking P.T. Barnum’s prophetic words and proving them true, playing on our desire to do just about anything to speed up the recovery from a bad hangover. And in fact, two new ones are in the news today.
blowfish-tablets

Blowfish

Several news outlets, such as the NY Daily News, have the story that Blowfish tablets, recently approved by the FDA, is on the market, available for sale over-the-counter. The effervescent tablets “combine 1,000 milligrams of aspirin, 120 milligrams of caffeine and a stomach-soothing agent” which you dissolve in water the morning after. “Once dissolved in water, the remedy claims to knock out multiple hangover symptoms in just 15 to 30 minutes.” So far, it’s only for sale in New York City or at ForHangovers.com, and sells for $2.99 for a single dose, or $11.99 for a six-pack. Hmm.
hangover-patch

The Vitamin Patch

The Daily has a story today regarding a patch that you wear on your arm — like a nicotine patch — that time releases B vitamins. “Bytox Inc., has created a hangover patch that slowly releases a complex of B vitamins over eight hours — from the hour before you start drinking to the morning after. The idea, said Dr. Leonard Grossman, is that nutrients are immediately delivered into the bloodstream and stay there instead of being depleted.”

Maybe, but that still seems like a lot of work when taking one pill before bedtime is so simple. Plus, you’d still need to keep drinking a lot of water, too. I continue to think that moderation is the best method, and when that fails, as it inevitably will on occasion, time is your only friend.

{ 2 comments }

Real Bar Flies Prefer Pale Ale

by Jay Brooks on November 28, 2011 · 2 comments

in Beers,Just For Fun,News

fly
A new study was reported last week by NPR about research into why insects are drawn to beer. When I was a kid, I remember my Great Aunt placing beer in shallow bowls and laying them on the floor around her house to attract, and drown, pesky insects. I’d always assumed that was because of the sugars in beer and the fact that many, if not most, insects are drawn to sweet flavors.

So scientists in Southern California looked closer at this phenomenon and published their results in Nature Neuroscience. The article, inscrutably titled Evolutionary Differences in Food Preference Rely on Gr64e, a Receptor for Glycerol, finds insights “into the molecular mechanisms of feeding acceptance of yeast products and raise the possibility that Gr64e contributes to specific evolutionary variations in appetitive selectivity across Drosophila species.”

Happily, the NPR article, clears up what that means:

Since flies are well known to like sugar, it could just be that flies like beer because they can detect some residual sugar in beer. But [researcher Anupama] Dahanukar suspected that might not be the case. So she planned an experiment. She would give the flies a choice between beer and sugar water, and see which they preferred.

“We selected a pale ale, and the main reason was because pale ales have very lower sugar contents,” says Dahanukar. “So we were trying to identify other chemicals — chemicals other than sugars that taste good to flies.”

Zev Wisotsky, a graduate student in Dahanukar’s lab, actually performed the experiment. “I remember it was a Saturday,” he says. “I grabbed the beer at the grocery store, came into the lab, and performed the two-choice assay.”

The two-choice assay forces the flies to choose between a sip of beer and a sip of sugar water. The flies went for the beer.

Figure 1: Feeding preference to yeast fermentation products is reduced in Gr64e mutants.
Figure 1 FINAL 9-2
(a) Feeding preference of wild-type flies (w1118) for beer (Bass & Co., Pale Ale) in a binary choice assay. For each concentration, n = 6. PI, preference index. (b) Feeding preference for beer, tested against 5 mM sucrose, in D. melanogaster…

Once they established the fly’s preference for beer, the scientists set about trying to figure out why.

“The answer, as it turns out, was quite simple,” says Dahanukar. “It’s a molecule called glycerol, which is made by yeast during fermentation.” Glycerol is the stuff that’s used in antifreeze. It actually tastes sweet, but it’s not a sugar.

Dahanukar and [researcher Zev] Wisotsky even found the particular gene responsible for flies’ ability to detect glycerol. When they created flies missing that gene, and gave them the sugar water-beer choice, the flies went for the sugar water.

Apparently, the ultimate purpose of the research is to understand how insects perceive chemicals in the hopes of designing better insect repellents. But for my money, I love the fact that they love Pale Ale.

{ 2 comments }

Updates On The Vodka & Tampon Hoax

November 21, 2011

You may recall my skeptical take on the Vodka and Tampon story two weeks ago. Since then, I got an e-mail from a friend with a link to a Tiny Cat Pants post In Which I Debunk the Vodka-Soaked Tampon Myth. Today, I learned from the Missus that Danielle Crittenden, Managing Editor, Blogs, for the [...]

Keep Reading →

Fomenting Female Fear

November 16, 2011

The purported scientific journal Alcoholism: Clinical and Experimental Research has just published another doozy, this one entitled The Legacy of Minimum Legal Drinking Age Law Changes: Long-Term Effects on Suicide and Homicide Deaths Among Women. The idea was to compare people drinking before the age was raised to 21 with when 18-year olds could still [...]

Keep Reading →

Drunk Off … Er, In Your Ass?

November 11, 2011

A mix of thanks and “how could you” to Stephen Beaumont for tweeting this story, because now that I know it, I can’t unknow it. According to Digital Journal, a growing trend among Phoenix, Arizona, area youths — disturbingly both girls and boys — is to get drunk by soaking a tampon in vodka and [...]

Keep Reading →

Drinking & Cultural Anthropology

October 28, 2011

BBC Magazine published online a couple of weeks ago an interesting piece on cultural anthropology as it relates to drinking patterns, entitled Viewpoint: Is the Alcohol Message All Wrong?. While the article itself I found compelling on its on, the way in which it was attacked in the voluminous number of comments is at least [...]

Keep Reading →

Scientific American Examines The Beer Glass

August 22, 2011

Scientific American posted an interesting article this morning entitled Does Your Beer Glass Matter?. Part of their “Anthropology in Practice” section, in it author Krystal D’Costa takes a look at the beer glass through history from early man up to the recent new glass designed by the Boston Beer Co. for their Samuel Adams Lager.

Keep Reading →

Dig, Drink And Be Merry

June 27, 2011

The current issue of Smithsonian magazine has an interesting article about archeologist Patrick McGovern, who’s at the University of Pennsylvania and his work uncovering evidence of early alcoholic beverages. His particular sub-field is molecular anthropology and he has a great book about his work titled Uncorking the Past. The Smithsonian piece is entitled Dig, Drink [...]

Keep Reading →

Beer Missing From MyPlate

June 3, 2011

Yesterday the USDA scrapped their old food pyramid in favor of a new nutritional chart. The new one is called MyPlate, and as you’d expect it’s shaped like a plate. It’s also a bit simpler than previous efforts, divided into just four groups: proteins, grains, fruit and vegetables. And just off the plate is a [...]

Keep Reading →

Good News: Beer Doesn’t Kill Brain Cells

May 25, 2011

You’ve probably heard this old saw your whole life, same as me, that “beer kills brain cells.” According to an item in this month’s Maxim, it turns out it just isn’t true. While alcohol can damage “neurons in the cerebellum that are responsible for motor control and memory, which helps create the impaired feeling we [...]

Keep Reading →

The Science Of Manipulation: New Study Comparing Underage Drinking Riddled With Problems

April 28, 2011

Join Together and the Partnership For a Drugfree America yesterday sent out an item in their e-mail blast entitled Teens Who Drink with Adult Supervision Have More Drinking Problems, Study Finds. Alarming, right? Likewise, the Seattle Post-Intelligencer’s went even farther with this misleading headline: UW study: Teens don’t need parents as ‘drinking buddies’. But do [...]

Keep Reading →

When Science Becomes Propaganda: The Caffeine & Alcohol Conundrum

April 18, 2011

Ugh. To me there’s nothing worse than junk science, especially when it’s in the service of an agenda. And that’s how this latest “study” in the journal Alcoholism: Clinical and Experimental Research comes across. The title of the “study” is Effects of Energy Drinks Mixed with Alcohol on Behavioral Control: Risks for College Students Consuming [...]

Keep Reading →