Historic Beer Birthday: William Lassell

June 18, 2025 By Jay Brooks

Today is the birthday of William Lassell (June 18, 1799–October 5, 1880). He made great contributions to astronomy throughout his life, but that “hobby” was funded by the fortune he made at his Liverpool brewery. He was initially trained as a merchant, and in 1825 started an apparently successful brewery, and one account states that he “married a widow of a wealthy Liverpool brewer gaining at the same time financial independence.” That may have given him the idea. Perhaps because his life was overshadowed by his astronomical pursuits, there’s very little about his brewery I could find, although I believe it was known as Lassell & Sharman Ltd.

Here’s his basic biography from his Wikipedia page:

William Lassell was born in Bolton, Lancashire, a town west of Manchester. He was educated first in Bolton then at Rochdale Academy. After the death of his father, he was apprenticed from 1814 to 1821 to a merchant in Liverpool. He then made his fortune as a beer brewer, which enabled him to indulge his interest in astronomy. He built an observatory at his house “Starfield” in West Derby, a suburb of Liverpool. There he had a 24-inch (610 mm) reflector telescope, for which he pioneered the use of an equatorial mount for easy tracking of objects as the Earth rotates. He ground and polished the mirror himself, using equipment he constructed. The observatory was later (1854) moved further out of Liverpool, to Bradstone.
In 1846 Lassell discovered Triton, the largest moon of Neptune, just 17 days after the discovery of Neptune itself by German astronomer Johann Gottfried Galle. In 1848 he independently co-discovered Hyperion, a moon of Saturn. In 1851 he discovered Ariel and Umbriel, two moons of Uranus.
When Queen Victoria visited Liverpool in 1851, Lassell was the only local she specifically requested to meet.
In 1855, he built a 48-inch (1,200 mm) telescope, which he installed in Malta because of the observing conditions that were better than in often-overcast England. On his return to the UK after several years in Malta he moved to Maidenhead and operated his 24-inch (610 mm) telescope in an observatory there. The 48-inch telescope was dismantled and was eventually scrapped.
Lassell was a Fellow of the Royal Astronomical Society (FRAS) from 1839, won the Gold Medal of the Royal Astronomical Society in 1849, and served as its president for two years starting in 1870. He was elected a Fellow of the Royal Society (FRS) in 1849 and won their Royal Medal in 1858. Lassel was also a Fellow of the Royal Society of Literature (FRSL). He was furthermore elected an honorary Fellow of the Royal Society of Edinburgh (HonFRSE) and of the Society of Sciences of Upsala, and received an honorary LL.D. degree from the University of Cambridge in 1874.
Lassell died in Maidenhead in 1880. Upon his death, he left a fortune of £80,000 (roughly equivalent to £7,200,000 in 2015). His telescope was presented to the Royal Observatory in Greenwich.
The crater Lassell on the Moon, a crater on Mars, the asteroid 2636 Lassell and a ring of Neptune are named in his honour.

This account of Lassell is from A Popular History of Astronomy During the Nineteen Century, by Agnes M. Clerke, published in 1885:

Within seventeen days of its identification with the Berlin achromatic, Neptune was found to be attended by a satellite. This discovery was the first notable performance of the celebrated two-foot reflector[224] erected by Mr. Lassell at his suggestively named residence of Starfield, near Liverpool. William Lassell was a brewer by profession, but by inclination an astronomer. Born at Bolton in Lancashire, June 18, 1799, he closed a life of eminent usefulness to science, October 5, 1818, thus spanning with his well-spent years four-fifths of the momentous period which we have undertaken to traverse. At the age of twenty-one, being without the means to purchase, he undertook to construct telescopes, and naturally turned his attention to the reflecting sort, as favouring amateur efforts by the comparative simplicity of its structure. His native ingenuity was remarkable, and was developed by the hourly exigencies of his successive enterprises. Their uniform success encouraged him to enlarge his aims, and in 1844 he visited Birr Castle for the purpose of inspecting the machine used in polishing the giant speculum of Parsonstown. In the construction of his new instrument, however, he eventually discarded the model there obtained, and worked on a method of his own, assisted by the supreme mechanical skill of James Nasmyth. The result was a Newtonian of exquisite definition, with an aperture of two, and a focal length of twenty feet, provided by a novel artifice with the equatoreal mounting, previously regarded as available only for refractors.
This beautiful instrument afforded to its maker, October 10, 1846, a cursory view of a Neptunian attendant. But the planet was then approaching the sun, and it was not until the following July that the observation could be verified, which it was completely, first by Lassell himself, and somewhat later by Otto Stuve and Bond of Cambridge (U.S.). When it is considered that this remote object shines by reflecting sunlight reduced by distance to 1/900th of the intensity with which it illuminates our moon, the fact of its visibility, even in the most perfect telescopes, is a somewhat surprising one. It can only, indeed, be accounted for by attributing to it dimensions very considerable for a body of the secondary order. It shares with the moons of Uranus the peculiarity of retrograde motion; that is to say, its revolutions, running counter to the grand current of movement in the solar system, are performed from east to west, in a plane inclined at an angle of 35 deg. to that of the ecliptic. Their swiftness serves to measure the mass of the globe round which they are performed. For while our moon takes twenty-seven days and nearly eight hours to complete its circuit of the earth, the satellite of Neptune, at a distance not greatly inferior, sweeps round its primary in five days and twenty-one hours, showing (according to a very simple principle of computation) that it is urged by a force seventeen times greater than the terrestrial pull upon the lunar orb. Combining this result with those of Professor Barnard’s and Dr. See’s recent measurements of the small telescopic disc of this farthest known planet, it is found that while in “mass” Neptune equals seventeen, in “bulk” it is equivalent to forty-nine earths. This is as much as to say that it is composed of relatively very light materials, or more probably of materials distended by internal heat, as yet unwasted by radiation into space, to about five times the volume they would occupy in the interior of our globe. The fact, at any rate, is fairly well ascertained, that the average density of Neptune is about twice that of water.

Historic Beer Birthday: Max Delbrück

June 16, 2025 By Jay Brooks

Today is the birthday of Max Emil Julius Delbrück (June 16, 1850-May 4, 1919). He was a German chemist who spent most of his career exploring the fermentation sciences.

His Wikipedia entry is short:

Delbrück was born in Bergen auf Rügen. He studied chemistry in Berlin and in Greifswald. In 1872 he was made assistant at the Academy of Trades in Berlin; in 1887 he was appointed instructor at the Agricultural College, and in 1899 was given a full professorship. The researches, carried out in part by Delbrück himself, in part under his guidance, resulted in technical contributions of the highest value to the fermentation industries. He was one of the editors of the Zeitschrift für Spiritusindustrie (1867), and of the Wochenschrift für Brauerei. He died in Berlin, aged 68.

And here’s his entry from Today in Science:

Max Emil Julius Delbrück was a German chemist who spent a forty-five year career leading development in the fermentation industry. He established a school for distillation workers, a glass factory for the manufacture of reliable apparatus and instruments, and an experimental distillery. Giving attention to the raw resources, he founded teaching and experimental institutions to improve cultivation of potatoes and hops. He researched physiology of yeast and application in the process of fermentation, production of pure cultures, and the action of enzymes. He started the journals Zeitschrift fur Spiritus-Industrie (1867) and Wochenschrift für Brauerei, for the alcohol and brewery industries, which he co-edited.

Over the years, I’ve found a few great Delbrück quotes:

“Yeast is a machine.”

— Max Delbrück, from an 1884 lecture

“With the sword of science and the armor of Practice, German beer will encircle the world.”

          — Max Delbrück, from an address about yeast and fermentation in the
               brewery, to the German Brewing Congress as Director of the Experimental
               and Teaching Institute for Brewing in Berlin, June 1884

Historic Beer Birthday: William S. Gossett

June 13, 2025 By Jay Brooks

Today is the birthday of William Sealy Gosset (June 13, 1876–October 16, 1937). He “was an English statistician. He published under the pen name Student, and developed the Student’s t-distribution.” He also worked his entire career for Guinness Brewing, and was trained as a chemist, but it was his pioneering work in statistics, in which he was self-taught, that he is best remembered for today.

Here’s his biography, from Wikipedia:

Born in Canterbury, England to Agnes Sealy Vidal and Colonel Frederic Gosset, Gosset attended Winchester College before studying chemistry and mathematics at New College, Oxford. Upon graduating in 1899, he joined the brewery of Arthur Guinness & Son in Dublin, Ireland.
As an employee of Guinness, a progressive agro-chemical business, Gosset applied his statistical knowledge – both in the brewery and on the farm – to the selection of the best yielding varieties of barley. Gosset acquired that knowledge by study, by trial and error, and by spending two terms in 1906–1907 in the biometrical laboratory of Karl Pearson. Gosset and Pearson had a good relationship. Pearson helped Gosset with the mathematics of his papers, including the 1908 papers, but had little appreciation of their importance. The papers addressed the brewer’s concern with small samples; biometricians like Pearson, on the other hand, typically had hundreds of observations and saw no urgency in developing small-sample methods.
Another researcher at Guinness had previously published a paper containing trade secrets of the Guinness brewery. To prevent further disclosure of confidential information, Guinness prohibited its employees from publishing any papers regardless of the contained information. However, after pleading with the brewery and explaining that his mathematical and philosophical conclusions were of no possible practical use to competing brewers, he was allowed to publish them, but under a pseudonym (“Student”), to avoid difficulties with the rest of the staff. Thus his most noteworthy achievement is now called Student’s, rather than Gosset’s, t-distribution.
Gosset had almost all his papers including The probable error of a mean published in Pearson’s journal Biometrika under the pseudonym Student. It was, however, not Pearson but Ronald A. Fisher who appreciated the importance of Gosset’s small-sample work, after Gosset had written to him to say I am sending you a copy of Student’s Tables as you are the only man that’s ever likely to use them!. Fisher believed that Gosset had effected a “logical revolution”. Fisher introduced a new form of Student’s statistic, denoted t, in terms of which Gosset’s statistic was {\displaystyle z={\frac {t}{\sqrt {n-1}}}} z=\frac{t}{\sqrt{n-1}}. The t-form was adopted because it fit in with Fisher’s theory of degrees of freedom. Fisher was also responsible for applications of the t-distribution to regression analysis.
Although introduced by others, Studentized residuals are named in Student’s honour because, like the problem that led to Student’s t-distribution, the idea of adjusting for estimated standard deviations is central to that concept.
Gosset’s interest in the cultivation of barley led him to speculate that the design of experiments should aim not only at improving the average yield but also at breeding varieties whose yield was insensitive to variation in soil and climate, i.e. robust. This principle only appeared in the later thought of Ronald Fisher, and then in the work of Genichi Taguchi during the 1950s.
In 1935, Gosset left Dublin to take up the position of Head Brewer, in charge of the scientific side of production, at a new Guinness brewery at Park Royal in northwestern London. He died two years later in Beaconsfield, England, of a heart attack.
Gosset was a friend of both Pearson and Fisher, a noteworthy achievement, for each had a massive ego and a loathing for the other. He was a modest man who once cut short an admirer with the comment that “Fisher would have discovered it all anyway.”

And this biography is from the MacTutor History of Mathematics archive:

William Sealey Gosset was born on June 13, 1876 in Canterbury, England where he was the oldest of five children. He died at the age of 61 in Beaconsfield, England on October 16, 1937. He attended the Royal Military Academy in Woolwich to b ecome an engineer before he was rejected because of poor eyesight. William Gosset was never employed as a statistician. In a world of quarrelsome statistics, but he got along with everyone. He was a very helpful, quiet, patient and loyal person.
He went to school at Winchester and was well educated before entering the New College in Oxford. Here he won a first degree in chemistry in 1899. After getting his degree as a chemist, he got a job at Guinness brewery in Dublin in 1899, where he did important work on statistics, but her was never hired at a statistician. It was his environment at Guinness’ that made him a statistician. The brewery was interested in how they could make the best beer.
In 1900, the Guinness Research Laboratory was opened, which was head by the most distinguished brewing chemist, Horace Brown. Horace Brown along with the other brews were wondering how to get the raw materials for brewing beer at the cheapest but getting the best. There were many factors that they had to take into account such as varieties of barley and hops, what conditions of dying, cultivation and maturing factors.
After a few years of research, given that they were given a free hand to explore the conditions of brewing. This gave Gosset a chance to work as a statistician. He was able to take the data from the different examples of brewing to help find out which way was the best. As the young brewers work together, it seemed natural for them to take the data to Gosset to solve the numerical problems.
Gosset, in 1903, could calculate standard errors. In 1904 he wrote on the brewing of beer. This report lead to Karl Pearson consulting Gosset. Gosset met Pearson in July of 1905 when they had long talk together. Pearson, in an hour and a half, m ade Gosset understand the theory of standard errors. Gosset went back to the brewery and practiced those method for the next year. The meeting was also successful in which Pearson got Gosset to take up the study of the law of error.
Gosset wrote paper in his spare time under the name “Student.” His paper were on the probability of error of the mean and of the correlation coefficient for publication. Gosset even managed to run cooperative experiments with Hunter a nd Bennett at Ballinacurra, Buffin at Cambridge, and Beaven at Warminster in the testing of seeds against other seeds. Gosset also work with R.A. Fisher. The funny part is that Fisher did not get along Pearson, but Gosset studied under Pearson and also got along with Fisher.
To quickly recap William Gosset, he was born in 1876 and died in 1937. He did mathematical research for beer brewing, but had the problem working with only a small sample size. He work on the concept of probable errror of a mean. He also analysi sed an extended and broad range of problems such as the counting with a haemacytometer, probable error of a correlation coefficient, cereals, agronomy and the Lanarkshire milk experiment.
A very personal friend, McMullen, said this about Gosset, “he was a very kindly and tolerant and absolutely devoid malice. He rarely spoke about personal matters but when his opinion was well worth listening to and not in the least superficia l.”

Pricenomics has a good overview of Gossett’s contributions to mathematics and statistics, entitled The Guinness Brewer Who Revolutionized Statistics.

Historic Beer Birthday: Carl von Linde

June 11, 2025 By Jay Brooks

Today is the birthday of Carl Paul Gottfried Linde (June 11, 1842–November 16, 1934). He “was a German scientist, engineer, and businessman. He discovered a refrigeration cycle and invented the first industrial-scale air separation and gas liquefaction processes. These breakthroughs laid the backbone for the 1913 Nobel Prize in Physics. Linde was a member of scientific and engineering associations, including being on the board of trustees of the Physikalisch-Technische Reichsanstalt and the Bavarian Academy of Sciences and Humanities. Linde was also the founder of what is now known as The Linde Group, the world’s largest industrial gases company, and ushered the creation of the supply chain of industrial gases as a profitable line of businesses. He was knighted in 1897 as Ritter von Linde.”

His importance to brewing, especially yo lager beers, is undeniable. His first refrigerating machines were built for breweries. This is situation prior to his inventions, from the University of Chicago:

Before the development of mechanical refrigeration technologies, brewers were reliant on ice harvested from lakes and ponds and stored in ice-houses. The invention of mechanical refrigeration machines provided commercial brewers with the technology necessary to keep beer for longer periods of time. Refrigeration technology was also used in special railroad boxcars, permitting brewers to ship their product over longer distances. One of the most successful early designs for a mechanical refrigeration system was invented by Carl von Linde (a professor at Munich Polytechnic School) and was an ammonia-based vapor-compression system.

eCopy, Inc. — One of the drawing from his first patent, in 1873.

This history of the development of Linde’s refrigeration machines is from a brochure prepared by his the company he founded, The Linde Group.

Initial contacts with breweries

After von Linde had published his ideas in 1870 and 1871 in the Polytechnic Association’s “Bavarian Industry and Trade Journal,” which he also edited, a development was set in motion that would determine the direction of the entire rest of his life. His articles on refrigeration technology had aroused the interest of brewers who had been looking for a reliable year-round method of refrigeration for the fermentation and storage of their beer. In the summer of 1871 an agreement was made between von Linde, Austrian brewer August Deiglmayr (Dreher Brewery) and Munich brewer Gabriel Sedlmayr to build a test machine according to Linde’s design at the Spaten Brewery. With their help, Linde’s ideas would be put into practice, so that a refrigeration unit could then be installed at the Dreher Brewery, the largest brewery in Austria, in the hot, humid city of Trieste (now part of Italy).

Building the first Linde ice machine

The construction plans were finally completed in January 1873 and the patent applied for. The Bavarian patent required, however, that the machine be in operation within one year. Therefore von Linde and Sedlmayr placed an order with Maschinenfabrik Augsburg that same month to build it. And with some effort they succeeded in starting operation by the important patent deadline in January 1874. Of course, the first machine did have its difficulties.

The main problem was that von Linde’s mercury seal did not work properly so that the methyl ether used as the refrigerant leaked out of the compressor. In Linde’s words, “This design was not a suitable solution for the requirements of practical use. So it seemed imperative to build a second machine.”

In order to finance it, von Linde assigned part of the patent rights to Sedlmayr, to locomotive builder Georg Krauss and to the director of Maschinenfabrik Augsburg, Heinrich von Buz. In return, they provided the funds needed for the development, building and testing of a new refrigeration machine.

linde-refrigeration-machine — Building the second refrigeration machine

With his student and assistant Friedrich Schipper, von Linde designed a new compressor, which had a significantly simpler and more effective seal. The sealing material used in the newly designed gland construction was glycerin and the more efficient ammonia was used as the refrigerant. The new machine weighed and cost only half as much as its predecessor.

In the spring of 1875 Linde ordered the new compressor from Maschinenfabrik Augsburg and submitted it for a Bavarian patent, which was awarded on March 25, 1876 for ten years. He received the German Reichspatent in August 1877.

“The very first trials with this second compressor yielded fully satisfactory results,” said von Linde, not without pride. The machine was sold to the Dreher Brewery in September 1876, erected under Schipper’s supervision and started up in spring 1877. It ran until 1908, providing refrigeration and dehumidification

Technical breakthrough

But despite this success, Linde created a third design immediately after the second machine was installed at Dreher, turning his attention to gas pumps, which were already widely used. This third, horizontal design proved to be the best cold vapor machine on the market in terms of its price/performance ratio and became the standard type of Linde compressor for decades to come. During the more than six-year development and experimentation phase, a reliable solution also had to be found for distributing the generated cold. After long trials, in executing an order for the Heineken Brewery in Rotterdam, von Linde developed a method of circulating cold saltwater brine in a pipe cooling system (natural convection cooling), which was installed on the ceiling of the refrigeration rooms.

horizontal-twostage-ammonia-compressor — And this inset is about the company’s “First customers and partners: brewers.”

In 1840, many continental European breweries switched to bottom fermented lager production (in contrast to the “English” top-fermented brown beers or ales) because the beer remained fresh longer and customers preferred the taste. The ice machine described by von Linde seemed ideal for achieving the required lower temperatures and to ensure precise cooling control. So it is no wonder that some major brewers showed great interest in this invention.
Gabriel Sedlmayr of the Munich Spaten Brewerey was willing to let von Linde experiment with an early refrigeration machine in his brewery in the early 1870s. The first unit functioned passably well, but was too large and had numerous flaws. The drawings submitted for the patent showed that Sedlmayr himself had a hand in the second version, which was significantly smaller in size and worked well. This unit was sold to the Trieste Dreher Brewery for air cooling.
With Sedlmayr as an intermediary, the Rotterdam Heineken Brewery under its director Feldmann ordered an ice machine in 1877 for ice production. In his collaboration with the Heineken Brewery, Linde developed “natural convection cooling” with a system of cooling pipes under the ceiling of the cellar. Feldmann in turn put von Linde in contact with J. C. Jacobsen, head of the Carlsberg Brewery in Copenhagen, who ordered a large refrigeration unit in 1878.
Karl Lang, technical adviser and supervisory board member of several Rhineland breweries, also played a significant role during the founding period of the “Gesellschaft für Linde’s Eismaschinen.” He introduced Linde to brewery director Gustav Jung, who not only ordered a refrigeration unit but also became, with Lang and banker Moritz von Hirsch, a shareholder and Supervisory Board member of the Linde Company.
The connection between the Linde Company and brewery directors was maintained to some extent over several generations. After the death of Karl Lang in 1894 his position as chairman of the Supervisory Board was taken over by Gustav Jung, followed by his son Adolf Jung in 1886. Carl Sedlmayr took over for his father Gabriel on the Supervisory Board and in 1915, the third generation of this family followed with Anton Sedlmayr. The Jung and Sedlmayr families held their Supervisory Board seats until after the Second World War.

Here’s Linde’s entry from the Oxford Companion to Beer, written by Horst Dornbush.

Linde, Carl von
was a 19th-century German engineer and one of the world’s major inventors of refrigeration technology. See refrigeration. Starting in the middle of the 18th century, many people before Linde had tinkered with artificial refrigeration contraptions, but Linde was the first to develop a practical refrigeration system that was specifically designed for keeping fermenting and maturing beer cool—in Linde’s case, Bavarian lagers—during the hot summer months. Linde was born in the village of Berndorf, in Franconia, in 1842, at a time when warm-weather brewing was strictly forbidden in his native Bavaria; no one was allowed to brew beer between Saint George’s Day (April 23) and Michael’s Day (September 29). This was to avoid warm fermentations, which provided ideal habitats for noxious airborne bacteria to proliferate and caused yeasts to produce undesirable fermentation flavors. Both made summer beers often unpalatable. Summer brewing prohibition had been in force since 1553 and was only lifted in 1850, by which time Bavarian brewers had learned to pack their fermentation cellars with ice they had laboriously harvested in the winter from frozen ponds and lakes. There had to be a better way to keep beer cold…and that was just the challenge for a budding mechanical engineering professor like Linde, who had joined Munich’s Technical University in 1868. See weihenstephan. The basic principle of refrigeration had been understood for centuries. Because cold is merely the absence of heat, to make things cold, one must withdraw heat. Compressing a medium generates heat; subsequently decompressing or evaporating it quickly absorbs heat from its environment. Devices based on this principle are now generally known as vapor-compression refrigeration systems; apply this to a fermenting or lagering vessel, and it becomes a beer-cooling system. For Linde, the next question was the choice of refrigerant. Initially he experimented with dimethyl ether but eventually settled on ammonia because of its rapid expansion (and thus cooling) properties. He called his invention an “ammonia cold machine.” Linde had received much of the funding for this development from the Spaten Brewery in Munich, which was also the first customer to install the new device—then still driven by dimethyl ether—in 1873. By 1879, Linde had quit his professorship and formed his own “Ice Machine Company,” which is still in operation today as Linde AG, headquartered in Wiesbaden, Germany. By 1890, Linde had sold 747 refrigeration units machines to various breweries and cold storage facilities. He continued to innovate and invented new devices most of his life, including equipment for liquefying air, and for the production of pure oxygen, nitrogen, and hydrogen. In 1897 he was knighted, and from then on could append the honorific “von” to his surname. He died a prosperous industrialist in Munich in 1934, at the age of 92, and today Linde AG is a leading gases and engineering company with almost 48,000 employees working in more than 100 countries worldwide. For all his many accomplishments, Linde’s pioneering work in artificial beer cooling technology is perhaps his most enduring legacy.

Historic Beer Birthday: Eduard Buchner

May 20, 2025 By Jay Brooks

nobel-prize
Today is the birthday of Eduard Buchner (May 20, 1860-August 13, 1917). Buchner was a German chemist and zymologist, and was awarded with Nobel Prize in Chemistry in 1907 for his work on fermentation.

This is a short biography from The Famous People:

Born into an educationally distinguished family, Buchner lost his father when he was barely eleven years old. His elder brother, Hans Buchner, helped him to get good education. However, financial crisis forced Eduard to give up his studies for a temporary phase and he spent this period working in preserving and canning factory. Later, he resumed his education under well-known scientists and very soon received his doctorate degree. He then began working on chemical fermentation. However, his experience at the canning factory did not really go waste. Many years later while working with his brother at the Hygiene Institute at Munich he remembered how juices were preserved by adding sugar to it and so to preserve the protein extract from the yeast cells, he added a concentrated doze of sucrose to it. What followed is history. Sugar in the presence of enzymes in the yeast broke into carbon dioxide and alcohol. Later he identified the enzyme as zymase. This chance discovery not only brought him Nobel Prize in Chemistry, but also brought about a revolution in the field of biochemistry.

Eduard Buchner is best remembered for his discovery of zymase, an enzyme mixture that promotes cell free fermentation. However, it was a chance discovery. He was then working in his brother’s laboratory in Munich trying to produce yeast cell free extracts, which the latter wanted to use in an application for immunology.

To preserve the protein in the yeast cells, Eduard Buchner added concentrated sucrose to it. Bubbles began to form soon enough. He realized that presence of enzymes in the yeast has broken down sugar into alcohol and carbon dioxide. Later, he identified this enzyme as zymase and showed that it can be extracted from yeast cells. This single discovery laid the foundation of modern biochemistry.

One of the most important aspects of his discovery proving that extracts from yeast cells could elicit fermentation is that it “contradicted a claim by Louis Pasteur that fermentation was an ‘expression of life’ and could occur only in living cells. Pasteur’s claim had put a decades-long brake on progress in fermentation research, according to an introductory speech at Buchner’s Nobel presentation. With Buchner’s results, “hitherto inaccessible territories have now been brought into the field of chemical research, and vast new prospects have been opened up to chemical science.”

In his studies, Buchner gathered liquid from crushed yeast cells. Then he demonstrated that components of the liquid, which he referred to as “zymases,” could independently produce alcohol in the presence of sugar. “Careful investigations have shown that the formation of carbon dioxide is accompanied by that of alcohol, and indeed in just the same proportions as in fermentation with live yeast,” Buchner noted in his Nobel speech.

E._Buchner_WS_1911-12

This is a fuller biography from the Nobel Prize organization:

Eduard Buchner was born in Munich on May 20, 1860, the son of Dr. Ernst Buchner, Professor Extraordinary of Forensic Medicine and physician at the University, and Friederike née Martin.
He was originally destined for a commercial career but, after the early death of his father in 1872, his older brother Hans, ten years his senior, made it possible for him to take a more general education. He matriculated at the Grammar School in his birth-place and after a short period of study at the Munich Polytechnic in the chemical laboratory of E. Erlenmeyer senior, he started work in a preserve and canning factory, with which he later moved to Mombach on Mainz.
The problems of chemistry had greatly attracted him at the Polytechnic and in 1884 he turned afresh to new studies in pure science, mainly in chemistry with Adolf von Baeyer and in botany with Professor C. von Naegeli at the Botanic Institute, Munich.
It was at the latter, where he studied under the special supervision of his brother Hans (who later became well-known as a bacteriologist), that his first publication, Der Einfluss des Sauerstoffs auf Gärungen (The influence of oxygen on fermentations) saw the light in 1885. In the course of his research in organic chemistry he received special assistance and stimulation from T. Curtius and H. von Pechmann, who were assistants in the laboratory in those days.
The Lamont Scholarship awarded by the Philosophical Faculty for three years made it possible for him to continue his studies.
After one term in Erlangen in the laboratory of Otto Fischer, where meanwhile Curtius had been appointed director of the analytical department, he took his doctor’s degree in the University of Munich in 1888. The following year saw his appointment as Assistant Lecturer in the organic laboratory of A. von Baeyer, and in 1891 Lecturer at the University.
By means of a special monetary grant from von Baeyer, it was possible for Buchner to establish a small laboratory for the chemistry of fermentation and to give lectures and perform experiments on chemical fermentations. In 1893 the first experiments were made on the rupture of yeast cells; but because the Board of the Laboratory was of the opinion that “nothing will be achieved by this” – the grinding of the yeast cells had already been described during the past 40 years, which latter statement was confirmed by accurate study of the literature – the studies on the contents of yeast cells were set aside for three years.
In the autumn of 1893 Buchner took over the supervision of the analytical department in T. Curtius’ laboratory in the University of Kiel and established himself there, being granted the title of Professor in 1895.
In 1896 he was called as Professor Extraordinary for Analytical and Pharmaceutical Chemistry in the chemical laboratory of H. von Pechmann at the University of Tübingen.
During the autumn vacation in the same year his researches into the contents of the yeast cell were successfully recommenced in the Hygienic Institute in Munich, where his brother was on the Board of Directors. He was now able to work on a larger scale as the necessary facilities and funds were available.
On January 9, 1897, it was possible to send his first paper, Über alkoholische Gärung ohne Hefezellen (On alcoholic fermentation without yeast cells), to the editors of the Berichte der Deutschen Chemischen Gesellschaft.
In October, 1898, he was appointed to the Chair of General Chemistry in the Agricultural College in Berlin and he also held lectureships on agricultural chemistry and agricultural chemical experiments as well as on the fermentation questions of the sugar industry. In order to obtain adequate assistance for scientific research, and to be able to fully train his assistants himself, he became habilitated at the University of Berlin in 1900.
In 1909 he was transferred to the University of Breslau and from there, in 1911, to Würzburg. The results of Buchner’s discoveries on the alcoholic fermentation of sugar were set forth in the book Die Zymasegärung (Zymosis), 1903, in collaboration with his brother Professor Hans Buchner and Martin Hahn. He was awarded the Nobel Prize in 1907 for his biochemical investigations and his discovery of non-cellular fermentation.
Buchner married Lotte Stahl in 1900. When serving as a major in a field hospital at Folkschani in Roumania, he was wounded on August 3, 1917. Of these wounds received in action at the front, he died on the 13th of the same month.

Chemistry-1907-Buchner

Historic Beer Birthday: Emil Christian Hansen

May 8, 2025 By Jay Brooks

carlsberg-crown
Today is the birthday of Emil Christian Hansen (May 8, 1842-August 27, 1909). Hansen was a “Danish botanist who revolutionized beer-making through development of new ways to culture yeast. Born poor in Ribe, Denmark, he financed his education by writing novels. Though he never reached an M.Sc., in 1876, he received a gold medal for an essay on fungi, entitled “De danske Gjødningssvampe.” In 1879, he became superintendent of the Carlsberg breweries. In 1883, he successfully developed a cultivated yeast that revolutionized beer-making around the world, because Hansen by refusing to patent his method made it freely available to other brewers. He also proved there are different species of yeast. Hansen separated two species: Saccharomyces cerevisiae, an over-yeast (floating on the surface of the fermenting beer) and Saccharomyces carlsbergensis, an under-yeast (laying on the bottom of the liquid).

Here’s his entry from Encyclopedia Britannica:

Danish botanist who revolutionized the brewing industry by his discovery of a new method of cultivating pure strains of yeast.
Hansen, who began his working life as a journeyman house painter, received a Ph.D. in 1877 from the University of Copenhagen. Two years later he was appointed head of the physiology department at the Carlsberg Laboratory in Copenhagen, where he remained until his death. His research was concerned mainly with yeasts that convert carbohydrates to alcohol, and in 1888 he published an article that described his method for obtaining pure cultures of yeast. The yeast grown from these single strains was widely adopted in the bottom-fermentation brewing industries. Further investigations led him to the discovery of a number of species of yeast. He defined the characters of the different species and devised a system of classification. After further study he devised additional methods for the culture and isolation of certain species.

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Emil Hansen as a young man.

This is how Carlsberg describes Hansen’s breakthrough in 1883:

The Carlsberg Laboratory made its first major scientific breakthrough when Dr. Emil Chr. Hansen developed a method for propagating pure yeast.
Fluctuations in the beer quality were not unknown at the time, but had until then been solved by thorough cleaning of all installations after suspension of production. If a brew failed, there was no use in pasteurising it; it had to be destroyed.
In 1883, the Old Carlsberg beer got infected with the beer disease and all efforts were made to find a solution to the problem.
Dr. Emil Chr. Hansen who joined the Carlsberg Laboratory in 1878 was examining the beer, and he found that it contained wild yeast. Through his studies and analyses, he discovered that only a few types of yeast (the pure yeast) are suitable for brewing, and he developed a technique to separate the pure yeast from the wild yeast cells. The problem had been solved, and the new Carlsberg yeast – Saccharomyces Carlsbergensis – was applied in the brewing process.
The propagating method revolutionised the brewing industry. Rather than to patent the process, Carlsberg published it with a detailed explanation so that anyone could build propagation equipment and use the method. Samples of the yeast – Saccharomyces Carlsbergensis – were sent to breweries around the world by request and young brewers came to Carlsberg to learn the skills.

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This is the entry from Wikipedia on the history of Saccharomyces Carlsbergensis:

So-called bottom fermenting strains of brewing yeast were described as early as the 14th century in Nuremberg and have remained an indispensable part of both Franconian and Bavarian brewing culture in southern Germany through modern times. During the explosion of scientific mycological studies in the 19th century, the yeast responsible for producing these so-called “bottom fermentations” was finally given a taxonomical classification, Saccharomyces pastorianus, by the German Max Reess in 1870.
In 1883 the Dane Emil Hansen published the findings of his research at the Carlsberg brewery in Copenhagen and described the isolation of a favourable pure yeast culture that he labeled “Unterhefe Nr. I” (bottom-fermenting yeast no. 1), a culture that he identified as identical to the sample originally donated to Carlsberg in 1845 by the Spaten Brewery of Munich. This yeast soon went into industrial production in Copenhagen in 1884 as Carlberg yeast no. 1.
In 1904 Hansen published an important body of work where he reclassified the separate yeasts he worked with in terms of species, rather than as races or strains of the same species as he had previously done. Here Hansen classified a separate species of yeast isolated from the Carlsberg brewery as S. pastorianus, a name derived from and attributed to Reess 1870. This strain was admitted to the Centraalbureau voor Schimmelcultures (CBS) in 1935 as strain CBS 1538, Saccharomyces pastorianus Reess ex Hansen 1904. In a further publication in 1908, Hansen reclassified the original “Unterhefe Nr. I” as the new species Saccharomyces carlsbergensis and another yeast “Unterhefe Nr. II” as the new species Saccharomyces monacensis. The taxonomy was attributed to Hansen 1908 and the yeasts entered into the Centraalbureau voor Schimmelcultures in 1947 as CBS 1513 and CBS 1503 respectively.
Since the early 1900s, bottom-fermenting strains of brewery yeast have been typically classified as S. carlbergensis in scientific literature, and the earlier valid name assigned to a bottom-fermenting yeast by Reess in 1870 was rejected without merit. This situation was rectified using DNA-DNA reallocation techniques in 1985 when Vaughan-Martini & Kurtzman returned the species name to S. pastorianus under the type strain CBS 1538 and relegated the two former species assigned by Hansen in 1908, S. carlsbergensis CBS 1513 and S. monacensis CBS 1503, to the status of synonyms. These experiments also clearly revealed the hybrid nature of the lager brewing yeast species for the first time, even though one of the parental species was incorrectly classified in retrospect. Nonetheless, over the last decades of the 20th century, debate continued in scientific literature regarding the correct taxon, with authors using both names interchangeably to describe lager yeast.

Although most accounts mention that he wrote novels to put himself through school, one has a slightly different take, though I’m not sure how true it is. “Emil earned his bread and butter as a painter but he yearned for another life and left Ribe so he could study. He graduated from High School relatively late – he was 29 years old.”

Emil Christian Hansen, taken in 1908, a year before his death.

Historic Beer Birthday: Anton Schwarz

February 2, 2025 By Jay Brooks

american-brewer-old
Today is the birthday of Anton Schwarz (February 2, 1839-September 24, 1895). In addition to having studied law, he also became a chemist and worked for several breweries in Budapest, before moving to the U.S. in 1868. Moving to New York, he got a job working for the magazine/journal American Brewer, which at the time was more like the People magazine of the brewing industry. He was quickly promoted to editor, eventually buying the publication. He turned it into a serious scientific journal, writing many of the articles himself, but is credited with helping the entire industry improve its standards and processes.

Anton-Schwarz

Here’s his entry from the Jewish Encyclopedia, published in 1906.

Austrian chemist; born at Polna, Bohemia, Feb. 2, 1839; died at New York city Sept. 24, 1895. He was educated at the University of Vienna, where he studied law for two years, and at the Polytechnicum, Prague, where he studied chemistry. Graduating in 1861, he went to Budapest, and was there employed at several breweries. In 1868 he emigrated to the United States and settled in New York city. The following year he was employed on “Der Amerikanische Bierbrauer” (“The American Brewer”) and soon afterward became its editor. A few years later he bought the publication, remaining its editor until his death. He did much to improve the processes of brewing in the United States, and in 1880 founded in New York city the Brewers’ Academy of the United States.
Schwarz’s eldest son, Max Schwarz (b. in Budapest July 29, 1863; d. in New York city Feb. 7, 1901), succeeded him as editor of “The American Brewer” and principal of the Brewers’ Academy. He studied at the universities of Erlangen and Breslau and at the Polytechnic High School at Dresden. In 1880 he followed his father to the United States and became associated with him in many of his undertakings.
Both as editor and as principal of the academy he was very successful. Many of the essays in “The American Brewer,” especially those on chemistry, were written by him. He was a great advocate of the “pure beer” question in America.

american-brewer-letterhead

When the United States Brewers’ Academy celebrated its 25th anniversary, in 1913, there was a ball where several alumni gave speeches and toasts, mentioning Schwarz’ contributions, including this from Gallus Thomann from Germany:

He also co-wrote the Theory and Practice of the Preparation of Malt and the Fabrication of Beer

Beer Advocate also has a nice story of Schwarz, entitled the O.G. Beer Geek.

Historic Beer Birthday: James Watt

January 19, 2025 By Jay Brooks

Today is the birthday of James Watt, not the BrewDog co-founder, but the “Scottish inventor, mechanical engineer, and chemist who improved on Thomas Newcomen’s 1712 Newcomen steam engine with his Watt steam engine in 1781, which was fundamental to the changes brought by the Industrial Revolution in both his native Great Britain and the rest of the world.

While working as an instrument maker at the University of Glasgow, Watt became interested in the technology of steam engines. He realised that contemporary engine designs wasted a great deal of energy by repeatedly cooling and reheating the cylinder. Watt introduced a design enhancement, the separate condenser, which avoided this waste of energy and radically improved the power, efficiency, and cost-effectiveness of steam engines. Eventually he adapted his engine to produce rotary motion, greatly broadening its use beyond pumping water.

Watt attempted to commercialise his invention, but experienced great financial difficulties until he entered a partnership with Matthew Boulton in 1775. The new firm of Boulton and Watt was eventually highly successful and Watt became a wealthy man. In his retirement, Watt continued to develop new inventions though none was as significant as his steam engine work. He died in 1819 aged 83.

He developed the concept of horsepower, and the SI unit of power, the watt, was named after him.”

186a,James Watt
A portrait of James Watt, by Carl Frederik von Breda, completed in 1792.

Of course, from our perspective his most important contribution was to the industrial revolution, and specifically the improvement of brewery efficiency. While Watt did not invent the steam engine, his improvements made it practical, especially in breweries.

The Watt Steam Engine

The Watt steam engine (alternatively known as the Boulton and Watt steam engine) was the first type of steam engine to make use of a separate condenser. It was a vacuum or “atmospheric” engine using steam at a pressure just above atmospheric to create a partial vacuum beneath the piston. The difference between atmospheric pressure above the piston and the partial vacuum below drove the piston down the cylinder. James Watt avoided the use of high pressure steam because of safety concerns. Watt’s design became synonymous with steam engines, due in no small part to his business partner, Matthew Boulton.
The Watt steam engine, developed sporadically from 1763 to 1775, was an improvement on the design of the Newcomen engine and was a key point in the Industrial Revolution.
Watt’s two most important improvements were the separate condenser and rotary motion. The separate condenser, located external to the cylinder, condensed steam without cooling the piston and cylinder walls as did the internal spray in Newcomen’s engine. Watt’s engine’s efficiency was more than double that of the Newcomen engine. Rotary motion was more suitable for industrial power than the oscillating beam of Newcomen’s engine.

watt-engine

Watt’s most famous steam engine was the one installed at the Whitbread Brewery in 1785, which was known as the Whitbread Engine. Today it’s located in the Powerhouse Museum in Sydney, Australia.

The Whitbread Engine

The Whitbread Engine preserved in the Powerhouse Museum in Sydney, Australia, built in 1785, is one of the first rotative steam engines ever built, and is the oldest surviving. A rotative engine is a type of beam engine where the reciprocating motion of the beam is converted to rotary motion, producing a continuous power source suitable for driving machinery.
This engine was designed by the mechanical engineer James Watt, manufactured for the firm Boulton and Watt and originally installed in the Whitbread brewery in London, England. On decommissioning in 1887 it was sent to Australia’s Powerhouse Museum (then known as the Technological, Industrial and Sanitary Museum) and has since been restored to full working order.

Installation of the Watt Steam Engine at Whitbread.

History of the Whitbread Engine

The engine was ordered by Samuel Whitbread in 1784 to replace a horse wheel at the Chiswell Street premises of his London brewery. It was installed in 1785, the second steam engine to be installed in a brewery, and enabled Whitbread to become the largest brewer in Britain. The horse wheel was retained for many years, serving as a backup in case the steam engine broke down. The drive gear of the engine, still evident today, was connected to a series of wooden line shafts which drove machinery within the brewery. Connected machinery included rollers to crush malt; an Archimedes’ screw, that lifted the crushed malt into a hopper; a hoist, for lifting items into the building; a three-piston pump, for pumping beer; and a stirrer within a vat. There was also a reciprocating pump connected to the engine’s beam, used to pump water from a well to a tank on the roof of the brewery.
In a marketing coup for both the brewer and the engine’s manufacturer, King George III and Queen Charlotte visited the brewery on 24 May 1787. The engine remained in service for 102 years, until 1887.
The engine made its way to the Powerhouse Museum (then known as the Technological, Industrial and Sanitary Museum) through Archibald Liversidge, an English-born chemist, scientist and academic at the University of Sydney, who was a trustee of the museum. Liversidge was in London in 1887, at the time of the engine’s decommissioning, and when he heard that the engine was to be scrapped he asked whether it could be donated to the museum. Whitbread & Co agreed on condition that the engine be set up and used for educational purposes.
Subsequently, the engine was dismantled and shipped to Sydney on the sailing ship Patriarch. For shipping purposes, the large flywheel was divided into two halves. While the flywheel’s rim could be unbolted, the hub with attached spokes had to be drilled through and rejoined after shipping. A shortage of funds meant the engine was kept in storage for several years. Eventually the engine was erected in its own engine house, behind the main building at the museum’s old Harris Street premises. During the 1920s or 1930s, an electric motor was added so that people could see the engine in motion. During the 1980s the Technology Restoration Society was formed in order to raise funds for the engine’s restoration. Restoration took place at the Museum’s Castle Hill site. During the restoration, some parts – including the piston – were replaced to preserve the original parts. The engine, restored to steaming condition, was installed in the new Powerhouse Museum in 1988. Today the engine is sometimes operated as part of the Museum’s Steam Revolution exhibition, steam being provided by the Museum’s central boiler.

watt-steam-engine

Technical specifications

The engine has a 0.64 metres (25 in) diameter piston with a 1.8 metres (6 ft) long stroke, driven by a mean effective pressure of 70 kilopascals (10 psi). Its top speed is 20 revolutions per minute (rpm) of the flywheel. In the engine’s youth, it had a maximum power output of approximately 26 kilowatts (35 hp).[It underwent a series of alterations in 1795, converting it from single-acting to double-acting; it was alleged at the time that this conversion improved its power to 52 kilowatts (70 hp), but the Powerhouse Museum claims this is false. A centrifugal governor, which moderates the level of steam provided if the engine begins to overload was added some years after this, and beam and main driving rod, both originally of wood, were replaced in sand-cast iron.
Apart from its age, the engine is notable in that it embodies the four innovations which made Boulton & Watt’s engines a significant driver of the Industrial Revolution. The first is a separate condenser, which increases the efficiency of the engine by allowing the main cylinder to remain hot at all times. The second is the parallel motion, which converts the up-and-down motion of the piston into the arcing motion of the beam, whilst maintaining a rigid connection. The rigid connection allowed the engine to be double-acting, meaning the piston could push as well as pull the beam. Third is the centrifugal governor, used to automatically regulate the speed of the engine. Finally the sun and planet gear convert the reciprocating motion of the beam into a rotating motion, which can be used to drive rotating machinery.

There’s also another Boulton & Watt engine at the National Museum of Scotland. It “was built in 1786 to pump water for the Barclay & Perkins Brewery in Southwark, London. Made double-acting in 1796, it was then capable of grinding barley and pumping water. At that time, no one else could supply a steam engine that performed both these actions at once. With some minor modifications, it remained in service at the brewery until 1884.”

boutonwattengine

And this is more from the National Museum of Scotland:

James Watt (1736-1819) was a prolific inventor, surveyor, instrument maker and engineer. His engines dramatically increased the power that could be generated through steam.
By entering into partnership with the Birmingham magnate Matthew Boulton in 1774, James Watt was able to channel the vast resource of Boulton’s Soho Foundry. Their partnership was so successful that the Boulton & Watt firm supplied engines and expertise to countries as far a field as Russia and Greece.
After pumping water and grinding barley for almost eighty-seven years, the engine came out of service in 1883.

You can see a diagram of the engine in action here:

Watt’s Steam Engine

Boulton-and-Watt-engine-1

Inside the Engine

Boulton-and-Watt-engine-2

Lighting the Fire

Boulton-and-Watt-engine-3

Running the Engine

Boulton-and-Watt-engine-4

If you want to read more in-depth about Watt’s development of the steam engine, Chapter III of “The Development of the Modern Steam-Engine: James Watt and His Contemporaries” is online, and there’s also various links at Watt’s page at the Scottish Engineering Hall of Fame.

Watt-postcard

Historic Beer Birthday: Louis Pasteur

December 27, 2024 By Jay Brooks

Today is the birthday of Louis Pasteur (December 27, 1822–September 28, 1895). He “was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization. He is remembered for his remarkable breakthroughs in the causes and preventions of diseases, and his discoveries have saved countless lives ever since. He reduced mortality from puerperal fever, and created the first vaccines for rabies and anthrax. His medical discoveries provided direct support for the germ theory of disease and its application in clinical medicine. He is best known to the general public for his invention of the technique of treating milk and wine to stop bacterial contamination, a process now called pasteurization. He is regarded as one of the three main founders of bacteriology, together with Ferdinand Cohn and Robert Koch, and is popularly known as the ‘father of microbiology.'”

Portrait of Louis Pasteur

But, of course, for the brewing industry, he’s best remembered for his “Studies on Fermentation,” which he published in 1876.

In 1876, Louis Pasteur published his ground-breaking volume, Études sur la Bière, soon translated into English as Studies On Fermentation. The book changed the course of brewing during the late 19th and early 20th centuries, representing a huge leap forward in the scientific understanding of the processes involved in beermaking. Brewers around the globe put Pasteur’s findings to work in their breweries, and thus plunged the industry headlong into the modern era.
In tribute to Pasteur’s tremendous contributions to brewing science, BeerBooks.com has reprinted Studies On Fermentation exactly as it appeared when first released in English, complete with all of Pasteur’s illustrations. An original 1879 edition was digitally scanned, professionally enhanced and reproduced in a hard cover format.
In his preface, Pasteur modestly wrote, “I need not hazard any prediction concerning the advantages likely to accrue to the brewing industry from the adoption of such a process of brewing as my study of the subject has enabled me to devise, and from an application of the novel facts upon which this process is founded. Time is the best appraiser of scientific work, and I am not unaware that an industrial discovery rarely produces all its fruits in the hands of its first inventor.”
But, of course, the brewing industry recognized almost immediately the impact that Pasteur’s work would have on the art and science of beermaking. Frank Faulkner, the British brewing scholar who performed the English translation, wrote, “Seeing the vast importance of Pasteur’s work from a practical point of view, after writing a review of it for the Brewers’ Journal, I determined to procure, at any rate for the use of my own pupils, a literal translation, illustrated by photo-lithographic copies of the original plates…It was on the completion of this translation that my views and desires expanded. The more I studied the work, the more I was convinced of its immense value to the brewer as affording him an intelligent knowledge of the processes and materials with which he deals…I determined accordingly to publish the work if I could secure the consent of its distinguished author…The debt which we English brewers owe to M[r]. Pasteur can hardly be over-estimated.”

While I’m sure there are probably many more, he had patents I highlighted last year, Patent No. 135245A: Improvement in Brewing Beer and Ale from 1873, and Patent No. 141072A: Manufacture of Beer and Yeast, in the same year.

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A portrait of Louis Pasteur painted by Swedish-speaking Finnish artist Albert Edelfelt, in 1886.

Fermentation and germ theory of diseases
Pasteur demonstrated that fermentation is caused by the growth of micro-organisms, and the emergent growth of bacteria in nutrient broths is due not to spontaneous generation, but rather to biogenesis (Omne vivum ex vivo “all life from life”). He was motivated to investigate the matter while working at Lille. In 1856 a local wine manufacturer, M. Bigot, the father of his student, sought for his advice on the problems of making beetroot alcohol and souring after long storage. In 1857 he developed his ideas stating that: “I intend to establish that, just as there is an alcoholic ferment, the yeast of beer, which is found everywhere that sugar is decomposed into alcohol and carbonic acid, so also there is a particular ferment, a lactic yeast, always present when sugar becomes lactic acid.” According to his son-in-law, Pasteur presented his experiment on sour milk titled “Latate Fermentation” in August 1857 before the Société des Sciences de Lille. (But according to a memoire subsequently published, it was dated November 30, 1857). It was published in full form in 1858. He demonstrated that yeast was responsible for fermentation to produce alcohol from sugar, and that air (oxygen) was not required. He also demonstrated that fermentation could also produce lactic acid (due to bacterial contamination), which makes wines sour. This is regarded as the foundation of Pasteur’s fermentation experiment and disprove of spontaneous generation of life.
Pasteur’s research also showed that the growth of micro-organisms was responsible for spoiling beverages, such as beer, wine and milk. With this established, he invented a process in which liquids such as milk were heated to a temperature between 60 and 100 °C. This killed most bacteria and moulds already present within them. Pasteur and Claude Bernard completed the first test on April 20, 1862. Pasteur patented the process, to fight the “diseases” of wine, in 1865. The method became known as pasteurization, and was soon applied to beer and milk.
Beverage contamination led Pasteur to the idea that micro-organisms infecting animals and humans cause disease. He proposed preventing the entry of micro-organisms into the human body, leading Joseph Lister to develop antiseptic methods in surgery. Lister’s work in turn inspired Joseph Lawrence to develop his own alcohol-based antiseptic, which he named in tribute Listerine.

This is an ad is for Whitbread, from 1937, showing an illustration of Louis Pasteur working on his fermentation studies in a laboratory at Whitbread Brewing in 1871, nine years after he completed his first test of pasteurization, which took place April 20, 1862.

On his Wikipedia page, under the heading “Controversies, there’s this paragraph about his research into fermentation:

When Pasteur published his theory and experiments on fermentation in 1858, it was not new to science, neither the idea nor the experiment. In 1840 a German chemist Justus von Liebig had noted that yeast could induce fermentation in water. However, he did not know that yeasts were organisms. In 1856 another German, Friedrich Wilhelm Lüdersdorff, reported that yeasts were microorganisms that convert sugar into alcohol. In 1855, Antoine Béchamp, Professor of Chemistry at the University of Montpellier, showed that sugar was converted to sucrose and fructose in a closed bottle containing water and when he added calcium or zinc chloride to it, no reaction occurred. He also noticed moulds developing in the solution, but could not fathom the significance of it. He concluded that water was the factor for fermentation. He changed his conclusion in 1858 that water was not the main factor, in fact, fermentation was directly related to the growth of moulds, and moulds required air for growth. He regarded himself as the first to show the role of microorganisms in fermentation. Pasteur started his experiments only in 1857 and published his findings in 1858 (April issue of Comptes Rendus Chimie, Béchamp’s paper appeared in January issue), which, as Béchamp noted, did not bring any novel idea or experiments that earlier works had not shown. On the other hand, Béchamp was probably aware of Pasteur’s 1857 preliminary works. With both scientists claiming priority on the discovery, a bitter and protracted dispute lasted throughout their lives. Their rivalry extended to ideas on microbiology, pathogenesis, and germ theory. Particularly on the spontaneous generation because Pasteur in his 1858 paper explicitly stated that the lactic acid bacteria (he named them “lactic yeasts”), which caused wine souring, “takes birth spontaneously, as easily as beer yeast every time that the conditions are favourable.” This statement directly implied that Pasteur did believe in spontaneous generation. He condemned the ideas of Pasteur as “‘the greatest scientific silliness of the age”. However, Béchamp was on the losing side, as the BMJ obituary remarked: His name was associated with bygone controversies as to priority which it would be unprofitable to recall. Pasteur and Béchamp believed that fermentation was exclusively cellular activity, that is, it was only due to living cells. But later extraction of enzymes such as invertase by Marcellin Berthelot in 1860 showed that it was simply an enzymatic reaction.

Pasteur’s ground-breaking “Studies on Fermentation” is in the public domain, of course, so you can read the entire work, or just browse through it, at the Internet Archive.

USBF-1951-qa9
In 1951, the United States Brewers Foundation featured Louis Pasteur in an ad, which was part of a series that used a Q&A format aimed at highlighting different positive aspects of beer and the brewing industry.

Historic Beer Birthday: Gerardus Johannes Mulder

December 27, 2024 By Jay Brooks

Today is the birthday of Gerardus Johannes Mulder (December 26, 1802–April 18, 1880). He “was a Dutch organic and analytical chemist,” who wrote several technical chemical publications analyzing various substances, including one entitled “The Chemistry of Beer,” in 1856 or 57 (sources vary).

“He became a professor of chemistry at Rotterdam and later at Utrecht. While at the Utrecht University, Mulder described the chemical composition of protein. He claimed that albuminous substances are made up of a common radical, protein, and that protein had the same empirical formula except for some variation in amounts of sulfur and phosphorus, long before the polymer nature of proteins was recognized after work by Staudinger and Carrothers.

He was the first to use this name, protein, coined by Jöns Jacob Berzelius in a publication, his 1838 paper ‘On the composition of some animal substances’ (originally in French but translated in 1839 to German). In the same publication he also proposed that animals draw most of their protein from plants.”

Gerardus_Johannes_Mulder

Here’s a biography of Mulder from Encyclopedia.com:

Mulder studied medicine at the University of Utrecht (1819–1825), from which he graduated with a dissertation on the action of alkaloids of opium, De opio ejusque principiis, actione inter se comparatis (1825). He practiced medicine in Amsterdam and then in Rotterdam, where he also lectured at the Bataafsch Genootschap der Proefondervindelijke Wijsbegeerte and taught botany to student apothecaries. At the foundation of a medical school at Rotterdam (1828), Mulder became lecturer in botany, chemistry, mathematics, and pharmacy. His attention was directed primarily to the practical training of his students. In 1840 Mulder succeeded N. C. de Fremery as professor of chemistry at the University of Utrecht. He applied for his retirement in 1868 and spent the rest of his life in Bennekom. Besides publishing on scientific subjects, Mulder took an active part in education, politics and public health. The works of Faraday and Berzelius exerted a great influence on him; his Leerboek voor Scheikundige werktuigkunde (1832–1835) was written in the spirit of Faraday’s Chemical Manipulation. Mulder edited a Dutch translation by three of his students of Berzelius’ textbook of chemistry as Leerboek der Scheikunde (6 vols., 1834–1845). His difficult character caused problems with some of his pupils and with other chemists.

From 1826 to 1865 Mulder edited five Dutch chemical journals (see bibliography), in which most of his work was published. He worked in physics and in both general and physical chemistry, the latter in combination with medicine, physiology, agriculture, and technology. Most of his work had a polemic character. His most important contributions are in the field of physiological chemistry and soil chemistry, in which he published two extensive works that attracted much attention in translation despite their many mistakes and erroneous speculations.

Studies on proteins led Mulder to his protein theory (1838): he supposed that all albuminous substances consist of a radical compound (protein) of carbon, hydrogen, nitrogen, and oxygen, in combination with varying amounts of sulfur and phosphorus. The differences among proteins resulted from multiplication of the protein units in conjunction with the two other elements. Thus, casein was formulated as

10 protein units + S,
And serum albumin as
10 protein units + SP2.

In 1843 Mulder published the first volume of a treatise on physiological chemistry, which was translated into English as The Chemistry of Vegetable and Animal Physiology (1845–1849). At first both Liebig and Berzelius accepted Mulder’s analysis of proteins; but Liebig soon opposed the theory vigorously, and a deep conflict with Mulder ensued. In 1839–1840 Mulder investigated humic and ulmic acids and humus substances and determined the amounts of geic acid (acidum geïcum), apocrenic acid (acidum apocrenicum or Quellsatzsäure), crenic acid (acidum crenicum or Quellsäure), and humic acids in fertile soils (1844). The structure of these various brown or black substances is unknown. They are a group of aromatic acids of high molecular weight, which can be extracted from peat, turf, and decaying vegetable matter in the soil. The difference between these acids is the oxygen content. In the decay of vegetable matter ulmic acid is formed. According to Mulder, this has the formula C20H14O6(in modern equivalents). In contact with air and water more oxygen is absorbed, which results in the successive formation of humic acid (C20H12O6, geic acid (C20H12O7), apocrenic acid C24H12O12, and crenic acid (C12H12O8).

His studies on agricultural chemistry led to the treatise De scheikunde der bouwbare aarde (1860). Mulder confirmed Berzelius’ suggestion that theine and caffeine are identical (1838) and was the first to analyze phytol correctly in his researches on chlorophyll. Among his other works are technical chemical publications on indigo (1833), wine (1855), and beer (1856), detailed research on the assaying method for analyzing silver in relation to the volumetric silver determination of Gay-Lussac (1857), and a study on drying oils (1865).

Gerrit-Jan-Mulder-01

While I can’t find the book itself, Julius E. Thausing mentions it in his “Theory and Practice of the Preparation of Malt and the Fabrication of Beer,”published in 1882.